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Up one levelPsychToolbox
The only production-level OS X package for running psychophysical experiments - requires Matlab
PyEPL
Michael Kahana has recently (2006) released a free Python-based Experiment Programming Library (PyEPL) to facilitate the development of computer-controlled cognitive tasks. The PyEPL is free software (under LGPL) and works on both Mac OSX and Linux. In addition to most standard experimental functions (e.g., timing, screen synchronization,etc.), PyEPL also provides functions for playing and recording sound rendering 3D virtual environments, and synchronizing experimental events with physiological recordings.
Congratulations to Jean, Giulia, and Adrian!